The fight against Alzheimer’s disease shows promising results with the potential of Lion’s Mane mushroom extract. Recent studies indicate its effectiveness in alleviating Alzheimer’s symptoms and protecting nerve cells from damage by targeting mitochondrial pathways. Known for cognitive benefits, this medicinal mushroom exhibits capabilities to reverse apoptotic changes, enhance cell viability, and minimize mitochondrial damage. Researchers are exploring alternatives to combat Alzheimer’s disease, a progressive cognitive disorder with grave consequences if left untreated. The study highlights the neuroprotective properties of Lion’s Mane mushroom in countering neuronal apoptosis associated with mitochondrial dysfunction, a key characteristic of Alzheimer’s disease. Utilizing animal and cellular models, the research showcases the mushroom’s therapeutic promise in potentially mitigating the detrimental effects of this brain-altering disease.