Herpes, commonly associated with skin manifestations, goes beyond the visible symptoms to potentially impact neurological and psychological health. Research has linked HHV-6 to mood disorders due to its ability to infect neurons, trigger neuroinflammation, and disrupt brain function, affecting cognition and emotional regulation. Recognizing this broader impact is essential for developing comprehensive treatment strategies and enhancing the quality of life for individuals affected by the virus. Keywords: herpes; neurological impact; psychological health; HHV-6; mood disorders.