Summer 2025 witnesses a significant COVID-19 surge across 25 US states, driven by fading immunity and new variants like NB.1.8.1 (Nimbus). The CDC reports rising infections following a biannual pattern, emphasizing the need for vaccination, masking, testing, and improved ventilation to curb transmission. The emergence of NB.1.8.1 (Nimbus) and other variants like XFG pose new challenges, underscoring the importance of protective measures.