Research indicates that prolonged sedentary behavior, even with regular exercise, elevates the risk of brain shrinkage and cognitive decline, particularly in older adults. The study, tracking participants over seven years, revealed a link between increased sitting time and neurodegenerative changes, irrespective of physical activity levels. The findings published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association suggest that sedentary behavior may independently increase the risk of Alzheimer’s disease. Older adults, especially those with genetic predispositions, need to minimize sitting time to safeguard their brain health and reduce cognitive decline.