Recent research suggests that incorporating about five walnuts daily may aid in reducing colon cancer risk due to their rich bioactive compounds. Studies indicate that whole walnuts are more effective than isolated nutrients, offering synergistic benefits. Consuming them raw or lightly roasted, as part of a balanced diet and healthy lifestyle, can contribute to cancer risk reduction. Cancer prevention through lifestyle and diet is gaining attention, with walnuts showing promise due to their unique blend of bioactive compounds. While studies on walnuts and colon cancer are promising, human trials are still limited, emphasizing the need for further research on the subject.